Hepatotoxicity in Rats Treated with Dimethylformamide or Toluene or Both

Hepatotoxicity in Rats Treated with Dimethylformamide or Toluene or Both

The effects of toluene in dimethylformamide (DMF)-induced hepatotoxicity were investigated with respect to the induction of cytochrome P-450 (CYP) and the activities of related enzymes. The rats were treated intraperitoneally with the organic solvents in olive oil (Single treatment groups: 450 [D1], 900 [D2], 1,800 [D3] mg DMF, and 346 mg toluene [T] per kg of body weight; Combined treatment gr...

HEPATOPROTECTIVE ACTIVITY OF SILYMARIN IN RATS TREATED WITH HIGH DOSES OF ACE T YLSA LICYLIC ACID OR NAPROXEN

Rats were treated with acetylsalicylic acid (150 mgikg b.w.per os daily) or naproxen (125 mg/kg b.w. per os daily) for six weeks. Half of the rats received silymarin (17.5 mgikg b.w. per os daily) in the last three weeks of the experiment. It was found tliat administration of acetylsalicylic acid led to signs of hepatic damage (an increase in serum bilirubin level, alanine aminotransferase ...

Speed Up, Slow Down or Both? Investigating the Contemporary Cities

Speed as a crucial phenomenon of modernism affects individual and collective life of human being and changes the traits of the places people live in. Increasing speed is the demand of the modern era, though on the other side in recent years there is a contrary incline towards slowing down different aspects of life. In view of this, the dualities in between social features of Speed up and slow d...

C-Labeled Benzene or Toluene

BCL-2 and Bax Expression in Skin Flaps Treated with Finasteride or Azelaic Acid

Despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. Therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. In present study, we evaluated the effect of azelaic acid 20% and finasteride on ex...